Clonal cytogenetic abnormalities in patients with chronic myeloid leukemia in complete cytogenetic response to imatinib mesylate

被引:0
|
作者
Espinet, Blanca [1 ,3 ]
Carla Oliveira, Ana [2 ]
Boque, Concepcion [2 ]
Domingo, Alicia [2 ]
Alonso, Esther [2 ]
Sole, Francesc [1 ,3 ]
机构
[1] Hosp del Mar, Lab Citogenet & Biol Mol, Serv Patol, IMAS,URNHE PRBB, Barcelona, Spain
[2] Hosp Univ Bellvitge, Serv Hematol, ICO, Barcelona, Spain
[3] Escola Citol Hematol Soledad Woessner IMAS, Barcelona, Spain
关键词
chronic myeloid leukemia; clonal cytogenetic abnormalities; imatinib;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The emergence of clonal chromosomal abnormalities in Philadelphia-negative cells during treatment with imatinib in patients with Philadelphia-positive chronic myeloid leukemia has been reported. We add information to this issue presenting a series of 29 patients in complete cytogenetic response after imatinib treatment, three of whom developed clonal aberrations.
引用
收藏
页码:556 / 558
页数:4
相关论文
共 50 条
  • [21] Complete Cytogenetic Response, Not Deep Molecular Response, Is Associated With Survival in Chronic Myeloid Leukemia
    Kantarjian, Hagop
    Cortes, Jorge E.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) : 3077 - 3077
  • [22] Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression
    Marktel, S
    Marin, D
    Foot, N
    Szydlo, R
    Bua, M
    Karadimitris, A
    De Melo, VAS
    Kotzampaltiris, P
    Dazzi, F
    Rahemtulla, A
    Olavarria, E
    Apperley, JF
    Goldman, JM
    HAEMATOLOGICA, 2003, 88 (03) : 260 - 267
  • [23] Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib
    Marin, D
    Kaeda, JS
    Andreasson, C
    Saunders, SM
    Bua, M
    Olavarria, E
    Goldman, JM
    Apperley, JF
    CANCER, 2005, 103 (09) : 1850 - 1855
  • [24] Molecular analysis of the Imatinib-induced complete cytogenetic response in chronic myelogenous leukemia
    Miglino, Maurizio
    Grasso, Raffaella
    Varaldo, Riccardo
    Fugazza, Giuseppina
    Colombo, Nicoletta
    Clavio, Marino
    Canepa, Letizia
    Garuti, Anna
    Ibatici, Adalberto
    Pierri, Ivana
    Ballerini, Filippo
    Sessarego, Mario
    Gobbi, Marco
    LEUKEMIA & LYMPHOMA, 2006, 47 (07) : 1348 - 1351
  • [25] Mean cell volume can be an early predictor for the cytogenetic response of chronic myeloid leukemia patients treated with imatinib?
    Song, Moo-Kon
    Chung, Joo-Seop
    Seol, Young-Mi
    Kim, Seong-Geun
    Shin, Ho-Jin
    Choi, Young-Jin
    Cho, Goon-Jae
    LEUKEMIA RESEARCH, 2009, 33 (11) : 1459 - 1462
  • [26] Hematopathologic and cytogenetic findings in imatinib mesylate treated chronic myelogenous leukemia patients: 2.5 years' experience
    Cojbasic, Irena
    Macukanovic-Golubovic, Lana
    VOJNOSANITETSKI PREGLED, 2010, 67 (10) : 802 - 806
  • [27] Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response
    Qin, Y. Z.
    Liu, Y. R.
    Zhu, H. H.
    Li, J. L.
    Ruan, G. R.
    Zhang, Y.
    Jiang, Q.
    Jiang, H.
    Li, L. D.
    Chang, Y.
    Huang, X. J.
    Chen, S. S.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2008, 30 (04) : 317 - 323
  • [28] Lower than expected cytogenetic and molecular response to imatinib in Mexican patients with chronic myelogenous leukemia
    Homero Gutierrez-Aguirre, Cesar
    Garcia-Rodriguez, Fernando
    Manuel Ortiz-Galvez, Victor
    Graciela Cantu-Rodriguez, Olga
    Salazar-Riojas, Rosario
    Lizzette Martinez-Gonzalez, Odra
    Gonzalez-Llano, Oscar
    Carlos Jaime-Perez, Jose
    Ortiz-Lopez, Rocio
    Antonio Flores-Jimenez, Juan
    Alatorre-Ricardo, Julio
    Mancias-Guerra, Consuelo
    Gomez-Almaguer, David
    HEMATOLOGY, 2013, 18 (04) : 224 - 229
  • [29] Complete Cytogenetic Response, Not Deep Molecular Response, Is Associated With Survival in Chronic Myeloid Leukemia Reply
    Hehlmann, Ruediger
    Hasford, Joerg
    Pfirrmann, Markus
    Lauseker, Michael
    Saussele, Susanne
    Hochhaus, Andreas
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) : 3078 - +
  • [30] Performance of Sokal and Eutos Scores for Predicting Cytogenetic and Molecular Response in Newly Diagnosed Chronic Myeloid Leukemia-Chronic Phase Patients on Imatinib
    Ganguly, Sandip
    Lakshmaiah, K. C.
    Jacob, Linu Abraham
    Babu, Suresh
    Dasappa, Lokanatha
    Babu, K. S. Govind
    INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2017, 33 (01) : 82 - 86