An efficient asymmetric synthesis of (S)-atenolol:: using hydrolytic kinetic resolution

被引：66

作者：

Bose, DS ^{[1
]}

Narsaiah, AV ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Fine Chem Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 03期

关键词：

beta-blockers; atenolol; Jacobsen catalyst; enantiomers; isopropylamine;

D O I：

10.1016/j.bmc.2004.10.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomerically pure (S)-atenolol was prepared by using (R,R) salen Co(III) complex for the resolution of terminal epoxide. This process was carried out at room temperature in excellent enantio selectivity. The method can be applied for large-scale preparation of (S)-atenolol without any problem. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：627 / 630

页数：4

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