Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse

被引：3
作者：
Piccinin, Elena [1 ]
Arconzo, Maria [2 ]
Graziano, Giusi [2 ]
Vacca, Michele [3 ]
Peres, Claudia [2 ]
Bellafante, Elena [4 ]
Villani, Gaetano [5 ]
Moschetta, Antonio [1 ,2 ]
机构：
[1] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy
[2] Natl Inst Biostuct & Biosyst, INBB, I-00136 Rome, Italy
[3] Addenbrookes Hosp, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Box 289, Cambridge CB2 0QQ, England
[4] Fdn Mario Negri Sud, I-66030 Chieti, Italy
[5] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期
关键词：
liver metabolism; liver diseases; coactivators; PGC-1; microRNA; ACTIVATED RECEPTOR-GAMMA; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL BIOGENESIS; COACTIVATOR PGC-1-ALPHA; CIRCULATING MICRORNAS; INDUCIBLE COACTIVATOR; URSODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR; CELLULAR SENESCENCE;
D O I：
10.3390/ijms20225735
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-gamma coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
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页数：18
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