HOXA13 is associated with unfavorable survival and acts as a novel oncogene in prostate carcinoma

被引：30
|
作者：
Dong, Yan [1 ,2 ]
Cai, Ying [3 ]
Liu, Bo [4 ]
Jiao, Xiang [1 ]
Li, Zhong-tai [1 ]
Guo, Da-yong [1 ]
Li, Xin-wei [1 ]
Wang, Yong-jun [1 ]
Yang, Deng-ke [1 ]
机构：
[1] 159th Hosp PLA, Dept Urol, Zhumadian, Peoples R China
[2] Third Mil Med Univ, Southwest Hosp, Dept Oncol, Chongqing, Peoples R China
[3] Third Mil Med Univ, Inst Toxicol, Coll Prevent Med, Chongqing, Peoples R China
[4] 159th Hosp PLA, Dept Burns & Plast Surg, Zhumadian, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 17期
关键词：
HOXA13; oncogene; overall survival; prognostic factor; prostate cancer; ABERRANT EXPRESSION; GENE-EXPRESSION; CANCER; MARKER; GROWTH;
D O I：
10.2217/fon-2016-0522
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To investigate the clinical relevance and functional role of HOXA13 in prostate cancer Methods: PCR, western blot and immunohistochemistry were performed to determine the expression. Kaplan-Meier and Cox regression survival analyses investigated the clinical relevance. Cell viability, flow cytometry and transwell assays were used to determine the functional roles. Results: HOXA13 expression is sharply increased in carcinoma tissues and is significantly associated with poor prognosis of prostate cancer patients. Interestingly, nucleus not cytoplasm HOXA13 expression is associated with unfavorable survival of the patients. Furthermore, nucleus HOXA13 expression represents an unfavorable and independent prognosis factor of histological grade 2 or Gleason grade <8 patients. Functionally, forced expression of HOXA13 obviously promotes tumor cell proliferation, migration and invasion, whereas inhibits tumor cell apoptosis. Conclusion: HOXA13 is an unfavorable prognostic factor and a novel oncogene for prostate cancer.
引用
收藏
页码：1505 / 1516
页数：12
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