Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China

被引：11
作者：
Gao, Ting [1 ]
Wu, Jiong [1 ]
Zheng, Ran [1 ]
Fang, Yi [1 ]
Jin, Chong-Yao [1 ]
Ruan, Yang [1 ]
Cao, Jin [1 ]
Tian, Jun [1 ]
Pu, Jia-Li [1 ]
Zhang, Bao-Rong [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Coll Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2020年 / 26卷 / 04期
基金：
中国国家自然科学基金;
关键词：
LINGO1; Parkinson's disease; PPARGC1A; single nucleotide polymorphism; GLUTAMATE TRANSPORTER SLC1A2; LINGO1; GENE; ASSOCIATION; POLYMORPHISMS; POPULATION; VARIANT; RS3794087; RISK;
D O I：
10.1111/cns.13272
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population. Methods A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect three essential tremor-related single nucleotide polymorphisms. Odds ratio (OR) and 95% confidential interval (CI) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility. Results Our results demonstrated that the odds ratios of rs3794087 of SLC1A2, rs9652490 of LINGO1, and rs17590046 of PPARGC1A were 0.71 (95% CI = 0.55-0.91), 0.99 (95% CI = 0.78-1.26), and 0.88 (95% CI = 0.62-1.25), respectively. Conclusion An essential tremor SNP (rs3794087 of SLC1A2) is associated with a decreased risk of PD in the Eastern Han Chinese population, while rs9652490 (LINGO1) and rs17590046 (PPARGC1A) do not show an association.
引用
收藏
页码：448 / 452
页数：5
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