Effect of preparation conditions on the size of nanoparticles based on poly (D,L-lactide-co-glycolide) synthesized with bismuth subsalicylate

被引：10
作者：
Razuvaeva, Ekaterina [1 ]
Sedush, Nikita [1 ]
Shirokova, Evgeniya [1 ]
Moskvichev, Stanislav [1 ]
Streltsov, Dmitry [1 ]
Chvalun, Sergei [1 ,2 ]
机构：
[1] Natl Res Ctr, Kurchatov Inst, Moscow 123182, Russia
[2] Russian Acad Sci, NS Enikolopov Inst Synthet Polymer Mat, Moscow 117393, Russia
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2022年 / 648卷
基金：
俄罗斯科学基金会;
关键词：
Lactide; Glycolide; Copolymerization; Bismuth subsalicylate; Nanoprecipitation; Nanoparticles; LOADED PLGA NANOPARTICLES; SMALL-ANGLE SCATTERING; PARTICLE-SIZE; IN-VITRO; COPOLYMERIZATIONS; NANOPRECIPITATION; HYDROCHLORIDE; CAPROLACTONE; DISPERSIONS; GLYCOLIDE;
D O I：
10.1016/j.colsurfa.2022.129198
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Spherical nano-sized particles of poly(D,L-lactide-co-glycolide) (PLGA) with molar composition of D,L-lactide and glycolide 75:25 mol.% synthesized with non-toxic catalyst bismuth subsalicylate were produced by a nanoprecipitation method. The effect of the formulation parameters (i.e. concentrations of PLGA in the organic phase and poly(vinyl alcohol) (PVA) in the aqueous phase) on the average hydrodynamic diameter, polydispersity index and electrokinetic potential of the PLGA particles was revealed. A formation mechanism of the PLGA particles based on the "nucleation and aggregation" model was proposed and supported by experimental data. Steric and electrokinetic stabilization factors of the PLGA particles were analyzed and discussed.
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页数：10
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