Effect of preparation conditions on the size of nanoparticles based on poly (D,L-lactide-co-glycolide) synthesized with bismuth subsalicylate

被引：8
作者：
Razuvaeva, Ekaterina [1 ]
Sedush, Nikita [1 ]
Shirokova, Evgeniya [1 ]
Moskvichev, Stanislav [1 ]
Streltsov, Dmitry [1 ]
Chvalun, Sergei [1 ,2 ]
机构：
[1] Natl Res Ctr, Kurchatov Inst, Moscow 123182, Russia
[2] Russian Acad Sci, NS Enikolopov Inst Synthet Polymer Mat, Moscow 117393, Russia
来源：
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2022年 / 648卷
基金：
俄罗斯科学基金会;
关键词：
Lactide; Glycolide; Copolymerization; Bismuth subsalicylate; Nanoprecipitation; Nanoparticles; LOADED PLGA NANOPARTICLES; SMALL-ANGLE SCATTERING; PARTICLE-SIZE; IN-VITRO; COPOLYMERIZATIONS; NANOPRECIPITATION; HYDROCHLORIDE; CAPROLACTONE; DISPERSIONS; GLYCOLIDE;
D O I：
10.1016/j.colsurfa.2022.129198
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Spherical nano-sized particles of poly(D,L-lactide-co-glycolide) (PLGA) with molar composition of D,L-lactide and glycolide 75:25 mol.% synthesized with non-toxic catalyst bismuth subsalicylate were produced by a nanoprecipitation method. The effect of the formulation parameters (i.e. concentrations of PLGA in the organic phase and poly(vinyl alcohol) (PVA) in the aqueous phase) on the average hydrodynamic diameter, polydispersity index and electrokinetic potential of the PLGA particles was revealed. A formation mechanism of the PLGA particles based on the "nucleation and aggregation" model was proposed and supported by experimental data. Steric and electrokinetic stabilization factors of the PLGA particles were analyzed and discussed.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Synthesis and characterization of novel maleated poly(d,l-lactide-co-glycolide) by direct melt copolymerization
    Zhihua Zhou
    Huihua Huang
    Tianlong Huang
    Cheng Peng
    Hu Zhou
    Qingquan Liu
    Wennan Zeng
    Lihua Liu
    Dafu Cao
    Siliang He
    Liujiao Xiang
    Hua Yan
    Polymer Bulletin, 2015, 72 : 1531 - 1543
  • [22] Preparation and evaluation of a stable and sustained release of lansoprazole-loaded poly(D,L-lactide-co-glycolide) polymeric nanoparticles
    Alsulays, Bader B.
    Anwer, Md Khalid
    Aldawsari, Mohammed F.
    Aodah, Alhussain
    Adam, Elsadig
    Alshehri, Sultan
    Abdel-Kader, Maged S.
    JOURNAL OF POLYMER ENGINEERING, 2019, 39 (09) : 822 - 829
  • [23] Evaluation of the antibacterial activity of poly-(D,L-lactide-co-glycolide) nanoparticles containing violacein
    Martins, D.
    Costa, F. T. M.
    Brocchi, M.
    Duran, N.
    JOURNAL OF NANOPARTICLE RESEARCH, 2011, 13 (01) : 355 - 363
  • [24] Resonance Raman Spectral Imaging of Intracellular Uptake of ß-Carotene Loaded Poly(D,L-lactide-co-glycolide) Nanoparticles
    Matthaeus, Christian
    Schubert, Stephanie
    Schmitt, Michael
    Krafft, Christoph
    Dietzek, Benjamin
    Schubert, Ulrich S.
    Popp, Juergen
    CHEMPHYSCHEM, 2013, 14 (01) : 155 - 161
  • [25] Design of experiments for the development of poly(d,l-lactide-co-glycolide) nanoparticles loaded with Uncaria tomentosa
    Ana Ferreira Ribeiro
    Carina Torres Garruth Ferreira
    Juliana Fernandes dos Santos
    Lúcio Mendes Cabral
    Valéria Pereira de Sousa
    Journal of Nanoparticle Research, 2015, 17
  • [26] Dispersion of super paramagnetic iron oxide nanoparticles in poly(D,L-lactide-co-glycolide) microparticles
    Wassel, Ronald A.
    Grady, Brian
    Kopke, Richard D.
    Dormer, Kenneth J.
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2007, 292 (2-3) : 125 - 130
  • [27] Uptake and cytotoxicity of poly(D,L-lactide-co-glycolide) nanoparticles in human colon adenocarcinoma cells
    Katsikari, A.
    Patronidou, Chr.
    Kiparissides, C.
    Arsenakis, M.
    MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS, 2009, 165 (03): : 160 - 164
  • [28] Possibilities of Poly(D,L-lactide-co-glycolide) in the Formulation of Nanomedicines Against Cancer
    Holgado, M. A.
    Alvarez-Fuentes, J.
    Fernandez-Arevalo, M.
    Arias, J. L.
    CURRENT DRUG TARGETS, 2011, 12 (08) : 1096 - 1111
  • [29] Pore formation and pore closure in poly(D,L-lactide-co-glycolide) films
    Fredenberg, Susanne
    Wahlgren, Marie
    Reslow, Mats
    Axelsson, Anders
    JOURNAL OF CONTROLLED RELEASE, 2011, 150 (02) : 142 - 149
  • [30] Mechanical Properties of (poly(L-lactide-co-glycolide))-Based Fibers Coated with Hydroxyapatite Layer
    Buczynska, Joanna
    Pamula, Elzbieta
    Blazewicz, Stanislaw
    JOURNAL OF APPLIED POLYMER SCIENCE, 2011, 121 (06) : 3702 - 3709
12345