Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives

被引：59

作者：

Carbone, Michele ^{[1
]}

Melino, Gerry ^{[2
,3
]}

机构：

[1] Univ Hawaii, Canc Ctr, Thorac Oncol, Honolulu, HI 96822 USA

[2] Univ Roma Tor Vergata, TOR, Dept Expt Med, Rome, Italy

[3] Univ Cambridge, Dept Pathol, Toxicol Unit, Med Res Council, Cambridge, England

来源：

CANCER RESEARCH | 2019年 / 79卷 / 20期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1158/0008-5472.CAN-19-2453

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Better therapies are urgently needed for ovarian cancer, which is associated with an overall median survival of less than 5 years from diagnosis. In this issue of Cancer Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in different isotypes of ovarian cancer and that SCD1 protects ovarian cancer cells from cell death. Pharmaceutical inhibition of SCD1 induces apoptosis and ferroptosis in vitro and in vivo. Combination therapies of SCD1 inhibitors and ferroptosis inducers significantly decrease ovarian tumor masses in mice. This novel therapy may prove useful to treat women with ovarian cancer.

引用

页码：5149 / 5150

页数：2

共 50 条

[31] Defining stearoyl-CoA desaturase 1 as a molecular therapeutic target against cholangiocarcinoma. [J].

Gleba, Justyna J. ;

Marlow, Laura A. ;

Miller, Erin E. ;

Miller, James L. ;

Alasonyalilar-Demirer, Aylin ;

Guo, Yi ;

Mody, Kabir ;

Roberts, Lewis R. ;

Alberts, Steven R. ;

Truty, Mark J. ;

Patel, Tushar C. ;

Copland, John A. .

CANCER RESEARCH, 2021, 81 (13)

[32] Stearoyl-CoA-Desaturase (SCD1) regulates lung cancer sternness via stabilization and nuclear localization of YAPfTAZ [J].

Noto, Alessia ;

Pisanu, Maria Elena ;

De Vitis, Claudia ;

Sorrentino, Giovanni ;

Del Sal, Giannino ;

Budillon, Alfredo ;

Ciliberto, Gennaro ;

Mancini, Rita .

CANCER RESEARCH, 2016, 76

[33] Erratum: Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ [J].

A Noto ;

C De Vitis ;

M E Pisanu ;

G Roscilli ;

G Ricci ;

A Catizone ;

G Sorrentino ;

G Chianese ;

O Taglialatela-Scafati ;

D Trisciuoglio ;

D Del Bufalo ;

M Di Martile ;

A Di Napoli ;

L Ruco ;

S Costantini ;

Z Jakopin ;

A Budillon ;

G Melino ;

G Del Sal ;

G Ciliberto ;

R Mancini .

Oncogene, 2017, 36 :4671-4672

[34] Expression of Stearoyl-CoA Desaturase (SCD) Is a New Predictor of Prostate Cancer Progression After Radical Prostatectomy [J].

Cheng, Jinrong ;

Xu, Bo ;

Gao, Chen ;

Feng, Yingdong ;

Mohler, James ;

Marshall, James .

LABORATORY INVESTIGATION, 2017, 97 :217A-217A

[35] Expression of Stearoyl-CoA Desaturase (SCD) Is a New Predictor of Prostate Cancer Progression After Radical Prostatectomy [J].

Cheng, Jinrong ;

Xu, Bo ;

Gao, Chen ;

Feng, Yingdong ;

Mohler, James ;

Marshall, James .

MODERN PATHOLOGY, 2017, 30 :217A-217A

[36] Stearoyl-CoA desaturase correlates with distant metastasis and poor survival in cancer. [J].

Song, K ;

Lee, I .

CLINICAL CANCER RESEARCH, 2005, 11 (24) :9068S-9068S

[37] NOVEL FUNCTIONS OF STEAROYL-COA DESATURASE IN THE SURVIVAL OF METASTATIC PROSTATE CANCER IN BONE [J].

Wilson, Alexis ;

Rajendran, Shrila ;

Mecca, Shane ;

Herroon, Mackenzie ;

Garmo, Laimar ;

Podgorski, Izabela .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2024, 79 (05) :8-8

[38] Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1 [J].

Jeyakumar, S. M. ;

Vajreswari, A. ;

Giridharan, N. V. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 370 (02) :243-247

[39] Hypoxia-responsive micelles deprive cofactor of stearoyl-CoA desaturase-1 and sensitize ferroptotic ovarian cancer therapy [J].

Luo, Jiajia ;

Shang, Yaqi ;

Zhao, Ning ;

Lu, Xiaoying ;

Wang, Zheng ;

Li, Xin ;

Meng, Xuan ;

Zhao, Yanjun .

BIOMATERIALS, 2025, 314

[40] The mutual effects of stearoyl-CoA desaturase and cancer-associated fibroblasts: A focus on cancer biology [J].

Mohammad, Suleiman Ibrahim ;

Vasudevan, Asokan ;

Alzewmel, Ahmad Hussein ;

Rab, Safia Obaidur ;

Ballal, Suhas ;

Kalia, Rishiv ;

Janney, J. Bethanney ;

Ray, Subhashree ;

Joshi, Kamal Kant ;

Yasin, Hatif Abdulrazaq .

EXPERIMENTAL CELL RESEARCH, 2025, 447 (02)

← 1 2 3 4 5 →