Base-sequence-dependent sliding of proteins on DNA

被引：28
作者：
Barbi, M
Place, C
Popkov, V
Salerno, M
机构：
[1] Univ Paris 06, Phys Theor Liquides Lab, F-75252 Paris 05, France
[2] Ecole Normale Super Lyon, Phys Lab, CNRS, UMR 5672, F-69364 Lyon, France
[3] Forschungszentrum Julich, Inst Festkorperforsch, D-52425 Julich, Germany
[4] Univ Salerno, Dipartimento Fis ER Caianiello, I-84081 Baronissi, SA, Italy
[5] Univ Salerno, INFM, I-84081 Baronissi, SA, Italy
来源：
PHYSICAL REVIEW E | 2004年 / 70卷 / 04期
关键词：
D O I：
10.1103/PhysRevE.70.041901
中图分类号：
O35 [流体力学]; O53 [等离子体物理学];
学科分类号：
070204 ; 080103 ; 080704 ;
摘要：
The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed.
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页数：6
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