heat shock;
DNA repair;
DNA damage;
DNA replication;
topoisomerase;
DOUBLE-STRAND BREAKS;
TOPOISOMERASE-II;
MAMMALIAN-CELLS;
S-PHASE;
HYPERTHERMIC RADIOSENSITIZATION;
SHOCK RESPONSE;
HISTONE H2AX;
CHO CELLS;
REPAIR;
INACTIVATION;
D O I:
10.32607/20758251-2016-8-2-75-78
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.