Heat Stress-Induced DNA Damage

被引:91
|
作者
Kantidze, O. L. [1 ]
Velichko, A. K. [1 ]
Luzhin, A. V. [1 ]
Razin, S. V. [1 ,2 ]
机构
[1] Russian Acad Sci, Inst Gene Biol, Vavilova Sfr 34-5, Moscow 119334, Russia
[2] Lomonosov Moscow State Univ, Fac Biol, Leninskie Gory 1,Bldg 12, Moscow 119991, Russia
来源
ACTA NATURAE | 2016年 / 8卷 / 02期
基金
俄罗斯科学基金会;
关键词
heat shock; DNA repair; DNA damage; DNA replication; topoisomerase; DOUBLE-STRAND BREAKS; TOPOISOMERASE-II; MAMMALIAN-CELLS; S-PHASE; HYPERTHERMIC RADIOSENSITIZATION; SHOCK RESPONSE; HISTONE H2AX; CHO CELLS; REPAIR; INACTIVATION;
D O I
10.32607/20758251-2016-8-2-75-78
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.
引用
收藏
页码:75 / 78
页数:4
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