Rice bran, an off-shoot to newer therapeutics in neurological disorders

被引:25
作者
Behl, Tapan [1 ]
Kumar, Sachin [2 ]
Sehgal, Aayush [1 ]
Singh, Sukhbir [1 ]
Kumari, Shilpa [2 ]
Brisc, Mihaela Cristina [3 ]
Munteanu, Mihai Alexandru [3 ]
Brisc, Ciprian [3 ]
Buhas, Camelia Liana [4 ]
Judea-Pusta, Claudia [4 ]
Nistor-Cseppento, Delia Carmen [5 ]
Bungau, Simona [6 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India
[2] Maharaja Ranjit Singh Punjab Tech Univ, Dept Pharmaceut Sci & Technol, Bathinda, Punjab, India
[3] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea, Romania
[4] Univ Oradea, Fac Med & Pharm, Dept Morphol Disciplines, Oradea, Romania
[5] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Recovery, Oradea, Romania
[6] Univ Oradea, Dept Pharm, Fac Pharm, Oradea, Romania
关键词
Neurodegeneration; Rice bran; Nutritional intake; Natural anti-oxidant; Anti-inflammation; gamma-oryzanol; INDUCED TARDIVE-DYSKINESIA; FERULIC ACID; OXIDATIVE STRESS; GAMMA-ORYZANOL; MITOCHONDRIAL DYSFUNCTION; EXTRAPYRAMIDAL SYMPTOMS; DROSOPHILA-MELANOGASTER; 3-NITROPROPIONIC ACID; ANTIOXIDANT ACTIVITY; HUNTINGTONS-DISEASE;
D O I
10.1016/j.biopha.2021.111796
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Normal brain functioning involves the interaction of interconnected molecular and cellular activities, which appear to alter normal to abnormal brain functioning when worsened, contributing to the emergence of neurological disorders. There are currently millions of people who are living with brain disorders globally and this will rise if suitable prevention strategies are not explored. Nutraceutical intended to treat numerous health goals with little adverse effect possible together can be more beneficial than pharmaceutical monotherapy for fostering balanced brain functioning. Nutraceutical provides a specific composition of effective macronutrients and micronutrients that are difficult to synthesize in the laboratory. Numerous elements of rice fibers in rice bran are characterized as natural anti-oxidant and having potential anti-inflammatory activity. The rice bran captures interest among the researchers as it is widespread, affordable, and rich in nutrients including protein, fat, carbohydrates, bioactive components, and dietary fiber. This review covers the neuroprotective multiplicity of rice bran and its constituents to deter pathological conditions of the brain and to facilitate balanced brain functioning at the same time.
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页数:12
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