New link between the RNA polymerase II-CTD and replication stress

被引：1

作者：

Landsverk, Helga B. ^{[1
]}

Sandquist, Lise E. ^{[1
]}

Bay, Lilli T. E. ^{[1
]}

Syljuasen, Randi G. ^{[1
]}

机构：

[1] Oslo Univ Hosp, Inst Canc Res, Norwegian Radium Hosp, Dept Radiat Biol, Ullernchausseen 70, N-0379 Oslo, Norway

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期

关键词：

Replication stress; transcription-replication conflicts; PP1; phosphatase; RNA polymerase II; PP1 nuclear targeting subunit (PNUTS); carboxy-terminal domain (CTD); WD repeat-containing protein 82 (WDR82);

D O I：

10.1080/23723556.2021.1910008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

引用

页数：2

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