The endocannabinoid system and amyloid-related diseases

被引：15
作者：
Ruiz-Valdepenas, Lourdes [1 ,2 ]
Benito, Cristina [1 ,2 ]
Maria Tolon, Rosa [1 ,2 ]
Martinez Orgado, Jose Antonio [3 ]
Romero, Julian [1 ,2 ]
机构：
[1] Hosp Univ Fdn Alcorcon, Lab Apoyo Invest, Alcorcon 28922, Spain
[2] Hosp Univ Fdn Alcorcon, CIBERNED, Alcorcon 28922, Spain
[3] Hosp Univ Puerta Hierro, Serv Pediat, Madrid 28222, Spain
来源：
EXPERIMENTAL NEUROLOGY | 2010年 / 224卷 / 01期
关键词：
CB2 CANNABINOID RECEPTOR; ALZHEIMERS-DISEASE; MICROGLIAL CELLS; IN-VITRO; DEFAULT NETWORK; LIPID RAFTS; MOUSE MODEL; FATTY-ACID; A-BETA; BRAIN;
D O I：
10.1016/j.expneurol.2010.03.024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The endocannabinoid system may be the target of novel therapies in a wide variety of diseases. Among them, those related with amyloid accumulation will be discussed in the present review. Several components of this system (CB1 and CB2 receptors, endocannabinoids, FAAH enzyme) may participate in different aspects of amyloid pathophysiology such as, for instance, synaptic activity, cell migration, cytokine production or phagocytic activity. Consistent with recent data, putative lines of research and hypothesis will be discussed. (C) 2010 Elsevier Inc. All rights reserved.
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收藏
页码：66 / 73
页数：8
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