Steroid hormone action on the amiloride-sensitive sodium channel (ASSC)

被引：0

作者：

Mirshahi, M ^{[1
]}

Mirshahi, S ^{[1
]}

Nicolas, C ^{[1
]}

Mishal, Z ^{[1
]}

Dagonet, F ^{[1
]}

Hecquet, C ^{[1
]}

Lounes, KC ^{[1
]}

D'Hermies, F ^{[1
]}

Pouliquen, Y ^{[1
]}

Agarwal, MK ^{[1
]}

机构：

[1] Ctr Cordeliers, INSERM U86, Paris, France

来源：

ADVANCES IN COMPARATIVE ENDOCRINOLOGY, TOMES 1 AND 2 | 1997年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Corticosteroid hormones are said to maintain hydrosodic balance by activating the apical, amiloride-sensitive sodium channel (ASSC) and the basolateral sodium pump in the epithelial layer of selected organs. We found that the mineralocorticoid receptor (MCR) and the ASSC were colocalized in both the epithelial and the nonepithelial ocular cells, rat osteoblasts and leukemic cell lines. The growth of all of these cell types was altered by steroids targeted for specificty to the MCR. Thus, the steroid hormone mediated action on the ASSC appears to be a wide spread feature of the living cell.

引用

页码：1273 / 1277

页数：5