[1] Hosp Ctr Sao Joao, Reprod Med Unit, Dept Gynecol & Obstet, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal
[2] Univ Porto ICBAS UP, Dept Microscopy, Cell Biol Lab, Inst Biomed Sci Abel Salazar, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal
[3] ICBAS UP, Multidisciplinary Unit Biomed Res UMIB, P-4050313 Oporto, Portugal
[4] Univ Porto, Fac Med, Dept Genet, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal
[5] Univ Porto, Inst Hlth Res Innovat, Rua Campo Alegre 823, P-4100 Oporto, Portugal