Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs

被引：180

作者：

Akdis, Cezmi A. ^{[1
,2
]}

Akdis, Muebeccel ^{[1
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[2] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

T-REGULATORY-CELLS; GRASS-POLLEN IMMUNOTHERAPY; TYPE-1; CELLS; BEE VENOM; INDUCTION; RESPONSES; MUCOSAL; ASTHMA; INFLAMMATION; SUPPRESSION;

D O I：

10.1172/JCI78891

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-/ suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-beta, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.

引用

页码：4678 / 4680

页数：3

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