Luteolin and cancer metastasis suppression: focus on the role of epithelial to mesenchymal transition

被引：35

作者：

Hussain, Yaseen ^{[1
]}

Cui, Jing Hao ^{[1
]}

Khan, Haroon ^{[2
]}

Aschner, Michael ^{[3
]}

Batiha, Gaber El-Saber ^{[4
]}

Jeandet, Philippe ^{[5
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 221400, Jiangsu, Peoples R China

[2] Abdul Wali Khan Univ Mardan, Dept Pharm, Mardan 23200, Pakistan

[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10463 USA

[4] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Egypt

[5] Univ Reims, Induced Resistance & Plant Bioprotect, Res Unit, EA 4707,SFR Condorcet FR CNRS 3417,Fac Sci, POB 1039, F-51687 Reims 2, France

来源：

MEDICAL ONCOLOGY | 2021年 / 38卷 / 06期

关键词：

Luteolin; Cancer metastasis; Epithelial to mesenchymal transition (EMT); Luteolin and EMT; DIETARY FLAVONOIDS LUTEOLIN; BREAST-CANCER; E-CADHERIN; COLON CARCINOGENESIS; CERVICAL-CANCER; BETA-CATENIN; CELLS; GROWTH; EMT; EXPRESSION;

D O I：

10.1007/s12032-021-01508-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial to mesenchymal transition (EMT) is a physiological process that assumes a primary role in the induction of cancer metastasis. This results in increased cell renewal, and resistance to cell death and therapies. EMT, therefore, represents an effective strategy for regulating cancerous cell activity. A need for efficacy and low cytotoxicity epithelial to mesenchymal transition modifying drugs has led to the investigational testing of the efficacy of plethora of different groups of phytonutrients. Luteolin is a natural flavonoid inhibits the growth of cancer cells by various mechanisms, such as the stimulation of cancer cell apoptosis, cell cycle arrest, inhibition of cell replication, tumor growth, improvement of drug resistance, prevention of cancer cell intrusiveness and metastasis. This review article focuses on the anti-cancer and anti-metastatic potential of luteolin targeting various transcription factors, markers and signaling pathways associated with the repression of epithelial to mesenchymal transition.

引用

页数：12

共 107 条

[81] Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: An implication for the antitumor potential of flavonoids [J].