A mussel-inspired poly(γ-glutamic acid) tissue adhesive with high wet strength for wound closure

被引:104
作者
Chen, Wei [1 ]
Wang, Rui [1 ]
Xu, Tingting [1 ]
Ma, Xuebin [2 ]
Yao, Zhong [1 ]
Chi, Bo [1 ]
Xu, Hong [1 ]
机构
[1] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, 30 South Puzu Rd, Nanjing 211816, Jiangsu, Peoples R China
[2] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
PORE-SIZE; PEG HYDROGELS; CELL-GROWTH; HEMOSTASIS; CHITOSAN; HEMORRHAGE; SCAFFOLDS; CHEMISTRY; SURFACES; EFFICACY;
D O I
10.1039/c7tb00813a
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Injectable hydrogels are promising candidates for adhesives because of their ease of administration, minimal invasion, and biocompatibility. While developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility have still been a significant challenge. Herein, inspired from nature, we report a novel mussel-inspired tissue-adhesive hydrogel composed of poly(gamma-glutamic acid) and dopamine (gamma-PGA-DA) that can bond tissues well and stop bleeding in a wet environment by improving its tissue adhesiveness via a horseradish peroxidasemediated reaction. The hydrogel exhibited 10-12 fold stronger wet tissue adhesion strength (58.2 kPa) over the clinically used fibrin glue and more effective hemostatic ability following liver impalement in animal models (41.2% reduction in the average amount of bleeding compared with fibrin glue). In addition, the hydrogels demonstrated controlled gelation time, swelling ratio, microscopic morphology, biodegradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility. The overall results suggest that the gamma-PGA-DA hydrogels can be considerably applied as promising wet-resistant adhesives and hemostatic materials.
引用
收藏
页码:5668 / 5678
页数:11
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