Glucose-6-phosphate dehydrogenase deficiency and severe neonatal hyperbilirubinemia: a complexity of interactions between genes and environment

被引：56

作者：

Kaplan, Michael ^{[1
,2
]}

Hammerman, Cathy ^{[1
,2
]}

机构：

[1] Shaare Zedek Med Ctr, Dept Neonatol, IL-91031 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2010年 / 15卷 / 03期

关键词：

Bilirubin; Glucose-6-phosphate dehydrogenase deficiency; Hemolysis; Kernicterus; Screening test; 1A1 PROMOTER POLYMORPHISM; DEHYDROGENASE-DEFICIENT; AFRICAN-AMERICAN; NEAR-TERM; CONJUGATED BILIRUBIN; X-CHROMOSOME; KERNICTERUS; HEMOLYSIS; JAUNDICE; RISK;

D O I：

10.1016/j.siny.2009.10.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Glucose-6-phosphate dehydrogenase deficiency is a commonly occurring genetic condition, likely to be encountered today in virtually any corner of the globe. Sudden episodes of hemolysis associated with the condition may result in exponential increases in serum total bilirubin concentrations to levels at which bilirubin-induced neurologic damage may occur. The hyperbilirubinemia is the result of complex interactions between genes and environment. Neonatal screening programs coupled with parental and medical caretaker education may be successful in limiting the severity of disease. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：148 / 156

页数：9

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