Protein function in the post-genomic era

被引：542

作者：

Eisenberg, D

Marcotte, EM

Xenarios, I

Yeates, TO

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, UCLA DOA Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA

来源：

NATURE | 2000年 / 405卷 / 6788期

关键词：

D O I：

10.1038/35015694

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of information but only flakes of knowledge. How can the thousands of sequences being determined and deposited, and the thousands of expression profiles being generated by the new array methods, be synthesized into useful knowledge? What form will this knowledge take? These are questions being addressed by scientists in the field known as 'functional genomics'.

引用

收藏

页码：823 / 826

页数：4

相关论文

共 26 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] Automatic extraction of keywords from scientific text: application to the knowledge domain of protein families [J].

Andrade, MA ;

Valencia, A .

BIOINFORMATICS, 1998, 14 (07) :600-607

[4] Predicting function: From genes to genomes and back [J].

Bork, P ;

Dandekar, T ;

Diaz-Lazcoz, Y ;

Eisenhaber, F ;

Huynen, M ;

Yuan, YP .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 283 (04) :707-725

[5] Exploring the new world of the genome with DNA microarrays [J].

Brown, PO ;

Botstein, D .

NATURE GENETICS, 1999, 21 (Suppl 1) :33-37

[6] Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].

不详 .

SCIENCE, 1998, 282 (5396) :2012-2018

[7] Comparison of the complete protein sets of worm and yeast: Orthology and divergence [J].

Chervitz, SA ;

Aravind, L ;

Sherlock, G ;

Ball, CA ;

Koonin, EV ;

Dwight, SS ;

Harris, MA ;

Dolinski, K ;

Mohr, S ;

Smith, T ;

Weng, S ;

Cherry, JM ;

Botstein, D .

SCIENCE, 1998, 282 (5396) :2022-2028

[8] Conservation of gene order: a fingerprint of proteins that physically interact [J].

Dandekar, T ;

Snel, B ;

Huynen, M ;

Bork, P .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (09) :324-328

[9] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

[10] Protein interaction maps for complete genomes based on gene fusion events [J].

Enright, AJ ;

Iliopoulos, I ;

Kyrpides, NC ;

Ouzounis, CA .

NATURE, 1999, 402 (6757) :86-90