The renin-angiotensin system in human brain and brain tumors : a function unrelated to blood pressure control?

被引：1
作者：
Juillerat-Jeanneret, L
Gasc, JM
Corvol, P
机构：
[1] CHU Vaudois, Inst Univ Pathol, CH-1011 Lausanne, Switzerland
[2] Coll France, INSERM U36, F-75005 Paris, France
来源：
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2004年 / 188卷 / 04期
关键词：
renin-angiotensin system; brain; apoptosis; permeability; blood-brain-barrier;
D O I：
10.1016/S0001-4079(19)33754-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The renin-angiotensin system (RAS), in addition to controlling blood pressure and the sodium-water balance, may be involved in cell growth and/or death in the brain. In order to address this issue, we compared the expression of RAS components in surgical specimens of human brain tumors and adjacent tissue. Human brain tumor cells and rat brain cells in culture were used to evaluate RAS functions. We found evidence that the RAS may be involved in maintaining the functions of the cerebral vasculature (the blood-brain-barrier) by controlling the ratio between angiotensin II and angiotensin III production, and by playing a more direct role in the survival of astroglial cells.
引用
收藏
页码：639 / 646
页数：8
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