Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?

被引：17

作者：

Cabanillas, Ruben

Rodrigo, Juan P.

Ferlito, Alfio ^{[1
]}

Rinaldo, Alessandra

Fresno, Manuel F.

Aguilar, Carolina

Alvarez, Marta E.

Suarez, Carlos

机构：

[1] Univ Udine, ENT Clin, Dept Surg Sci, I-33100 Udine, Italy

[2] Hosp Univ Cent Asturias, Dept Otorhinolaryngol, Oviedo, Spain

[3] Inst Univ Oncol Principado Asturias, Oviedo, Spain

[4] Hosp Univ Cent Asturias, Dept Pathol, Oviedo, Spain

[5] Hosp Univ Cent Asturias, Dept Microbiol, Oviedo, Spain

来源：

ORAL ONCOLOGY | 2007年 / 43卷 / 04期

关键词：

basaloid squamous cell carcinoma; conventional squamous cell carcinoma; differential diagnosis; HPV DNA; p53; pharynx;

D O I：

10.1016/j.oraloncology.2006.04.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidemiological link between Human Papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evatuated by polyrnerase chain reaction arnpiffication and "in situ" hybridization. The tobacco and alcohol consumption and the clinical outcomes of nine patients with BSCC of the pharynx are compared with site and stage matched 109 conventional squamous cell carcinoma (SCC) patients. The BSCC specimens were analyzed for the presence of HPV DNA and p53 expression. We did not find any significant differences in tobacco and alcohol consumption between patients with BSCC and patients with SCC. No HPV DNA was detected in BSCC, and p53 overexpression was found in five (55%) of the cases. Our results do not support an etiological link between HPV DNA and BSCC. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：327 / 332

页数：6

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