Ring contraction of 1,2,4-triazine derivatives in the synthesis of imidazoles

被引：20

作者：

Gazieva, G. A. ^{[1
]}

Karpova, T. B. ^{[1
,2
]}

Nechaeva, T. V. ^{[1
,3
]}

Kravchenko, A. N. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

[2] NPF Mat Med Holding Ltd, Build 1,47 Ul Trifonovskaya, Moscow 129272, Russia

[3] DI Mendeleev Univ Chem Technol Russia, 9 Miusskaya Pl, Moscow 125047, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2016年 / 65卷 / 09期

基金：

俄罗斯基础研究基金会;

关键词：

1,2,4-triazines; ring contraction; reduction; tandem reactions; oxidation; imidazoles; ANTITUMOR; SERIES;

D O I：

10.1007/s11172-016-1565-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The review systematizes the data on the reactions of 1,2,4-triazines proceeding with a triazine ring contraction to the imidazole one. Imidazole derivatives are obtained upon treatment of 1,2,4-triazines of different saturation degree with reducing agents, oxidants, acids, as well as with the agents initiating tandem reactions, the last step of which is a triazine ring contraction, for example, nitrosating and aminating agents, organometallic compounds and aromatic aldehydes.

引用

页码：2172 / 2182

页数：11

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