Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

被引:90
作者
Wrenn, CC [1 ]
Harris, AP [1 ]
Saavedra, MC [1 ]
Crawley, JN [1 ]
机构
[1] NIMH, Sect Behav Genom, Bethesda, MD 20892 USA
关键词
D O I
10.1037/0735-7044.117.1.21
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Social transmission of food preference (STFP) is a test of olfactory memory that can be used in mice. Confounds in STFP that can lead to misinterpretation of an STFP deficit as a memory impairment include changes in social interaction and olfaction. The issue of changes in social interaction was addressed by evaluating,an observer-centric and a demonstrator-centric method for scoring the interaction phase of STFP in mice. The demonstrator-centric method was applied to a line of STFP-impaired, galanin-overexpressing transgenic (GAL-tg). GAL-tg mice were impaired in STFP without deficits in social interaction. In tests of olfactory ability, GAL-tg mice were unimpaired on buried-food and habituation dishabituation tasks. The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice.
引用
收藏
页码:21 / 31
页数:11
相关论文
共 89 条
  • [81] Factors controlling measures of anxiety and responses to novelty in the mouse
    File, SE
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 125 (1-2) : 151 - 157
  • [82] EFFECTS OF ATROPINE ON DISCRIMINATION LEARNING IN RAT
    WHITEHOUSE, JM
    [J]. JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1964, 57 (01): : 13 - &
  • [83] Winocur G, 2001, HIPPOCAMPUS, V11, P18, DOI 10.1002/1098-1063(2001)11:1<18::AID-HIPO1016>3.0.CO
  • [84] 2-5
  • [85] Threshold relationship between lesion extent of the cholinergic basal forebrain in the rat and working memory impairment in the radial maze
    Wrenn, CC
    Lappi, DA
    Wiley, RG
    [J]. BRAIN RESEARCH, 1999, 847 (02) : 284 - 298
  • [86] Pharmacological evidence supporting a role for galanin in cognition and affect
    Wrenn, CC
    Crawley, JN
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (01) : 283 - 299
  • [87] WRENN CC, 2002, UNPUB MICROSTRUCTURE
  • [88] Galanin-5-hydroxytryptamine interactions: Electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors
    Xu, ZQD
    Zhang, X
    Pieribone, VA
    Grillner, S
    Hokfelt, T
    [J]. NEUROSCIENCE, 1998, 87 (01) : 79 - 94
  • [89] GALANIN REDUCES RELEASE OF ENDOGENOUS EXCITATORY AMINO-ACIDS IN THE RAT HIPPOCAMPUS
    ZINI, S
    ROISIN, MP
    LANGEL, U
    BARTFAI, T
    BENARI, Y
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1993, 245 (01): : 1 - 7