The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration

被引：75
作者：
Harrell, Carl Randall [1 ]
Djonov, Valentin [2 ]
Volarevic, Vladislav [3 ]
机构：
[1] Regenerat Proc Plant LLC, 34176 US Highway 19 N Palm Harbor, Palm Harbor, FL 34684 USA
[2] Univ Bern, Inst Anat, Baltzerstr 2, CH-3012 Bern, Switzerland
[3] Univ Kragujevac, Fac Med Sci, Dept Microbiol & Immunol, Ctr Mol Med & Stem Cell Res, 69 Svetozar Markovic St, Kragujevac 34000, Serbia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
mesenchymal stem cells; immune cells; immunomodulation; angiogenesis; regeneration;
D O I：
10.3390/ijms22052472
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
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页码：1 / 13
页数：13
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