A surface plasmon resonance-based technical platform for the detection of chromosome aneuploidy

被引：0
|
作者：
Wang, Shuyu [2 ]
Liu, Ning [1 ]
Jia, Chanwei [2 ]
Li, Ying [2 ]
Lan, Yonglian [2 ]
Chen, Zhong [1 ,3 ]
机构：
[1] GP Med Technol Ltd, Beijing 100176, Peoples R China
[2] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China
[3] Univ Utah, Sch Med, Div Med Genet, Salt Lake City, UT 84132 USA
来源：
CANCER GENETICS AND CYTOGENETICS | 2010年 / 200卷 / 02期
基金：
北京市自然科学基金; 中国国家自然科学基金;
关键词：
PROTEIN;
D O I：
10.1016/j.cancergencyto.2010.04.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Surface plasmon resonance (SPR)-based technologies have been widely used to study biomolecular interactions including receptor ligand, DNA protein, and protein protein interactions. In this pilot study, we used chromosome 21 as the genetic marker to appreciate the value of using SPR technology for the detection of chromosome aneuploidy. Four normal and four trisomy 21 samples were used in this study. Chromosomes 1 (as the internal control) and 21 specific sequence-tagged sites were used as markers for detection. Resonance unit ratios of chromosome 21 sequence-tagged site (STS) to chromosome 1 STS were calculated to interpret analytic results. The ratios in the normal samples ranged from 0.96 to 2.83, whereas in trisomy 21 samples, the ratios were from 6.96 to 16.30, significantly higher than those of the normal samples. These findings strongly indicate that SPR technology is suitable for the detection of trisomy 21. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：106 / 109
页数：4
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