Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: Thymidylate synthase mutagenesis, function, and structure

被引:107
作者
Finer-Moore, JS [1 ]
Santi, DV [1 ]
Stroud, RM [1 ]
机构
[1] Univ Calif San Francisco, Dept Biochem & Biophys S960, San Francisco, CA 94143 USA
关键词
D O I
10.1021/bi020599a
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:248 / 256
页数:9
相关论文
共 53 条
[1]   A novel dCMP methylase by engineering thymidylate synthase [J].
Agarwalla, S ;
LaPorte, S ;
Liu, L ;
Finer-Moore, J ;
Stroud, RM ;
Santi, DV .
BIOCHEMISTRY, 1997, 36 (50) :15909-15917
[2]   Crystal structure of a deletion mutant of human thymidylate synthase Δ(7-29) and its ternary complex with Tomudex and dUMP [J].
Almog, R ;
Waddling, CA ;
Maley, F ;
Maley, GF ;
Van Roey, P .
PROTEIN SCIENCE, 2001, 10 (05) :988-996
[3]   Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons [J].
Aurora, R ;
Rose, GD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :2818-2823
[4]   Trapping of the C5 methylene intermediate in thymidylate synthase [J].
Barrett, JE ;
Maltby, DA ;
Santi, DV ;
Schultz, PG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (02) :449-450
[5]   AMINO-ACID SEQUENCE AT FDUMP BINDING-SITE OF THYMIDYLATE SYNTHETASE [J].
BELLISARIO, RL ;
MALEY, GF ;
GALIVAN, JH ;
MALEY, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1848-1852
[6]   THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION CATALYZES PARTIAL REACTIONS BUT IS UNABLE TO CATALYZE THYMIDYLATE FORMATION [J].
CARRERAS, CW ;
CLIMIE, SC ;
SANTI, DV .
BIOCHEMISTRY, 1992, 31 (26) :6038-6044
[7]   Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis [J].
Chiericatti, G ;
Santi, DV .
BIOCHEMISTRY, 1998, 37 (25) :9038-9042
[8]   CHEMICAL SYNTHESIS OF THE THYMIDYLATE SYNTHASE GENE [J].
CLIMIE, S ;
SANTI, DV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :633-637
[9]  
CLIMIE S, 1990, J BIOL CHEM, V265, P18776
[10]   STRUCTURES OF REVERSIBLE AND IRREVERSIBLE COMPLEXES OF THYMIDYLATE SYNTHETASE AND FLUORINATED PYRIMIDINE NUCLEOTIDES [J].
DANENBER.PV ;
LANGENBA.RJ ;
HEIDELBE.C .
BIOCHEMISTRY, 1974, 13 (05) :926-933