Association of dopamine- and serotonin-related genes with canine aggression

被引：39
作者：
Vage, J. [1 ]
Wade, C. [2 ,3 ,4 ]
Biagi, T. [2 ]
Fatjo, J. [5 ]
Amat, M. [5 ]
Lindblad-Toh, K. [2 ,6 ]
Lingaas, F. [1 ]
机构：
[1] Norwegian Sch Vet Sci, Dept Basic Sci & Aquat Med, Div Genet, Oslo, Norway
[2] Broad Inst Harvard & MIT, Cambridge, MA USA
[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
[4] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia
[5] Univ Autonoma Barcelona, Fac Vet Barcelona, Dept Biol Cellular Fisiol & Immunol, E-08193 Barcelona, Spain
[6] Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden
来源：
GENES BRAIN AND BEHAVIOR | 2010年 / 9卷 / 04期
关键词：
Aggression; candidate genes; canine; dopamine; serotonin; SNP association; ENGLISH COCKER-SPANIELS; GOLDEN-RETRIEVER DOGS; BEHAVIOR; SYSTEM; POLYMORPHISMS; DISORDERS; TARGETS; TRAITS;
D O I：
10.1111/j.1601-183X.2010.00568.x
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Human-directed canine aggression was studied using 50 aggressive and 81 non-aggressive dogs. We examined 62 single nucleotide polymorphisms (SNPs) occurring in or in the close vicinity of 16 neurotransmitter-related genes. Allelic associations with aggression were identified for DRD1, HTR1D, HTR2C and SLC6A1. Risk or protective haplotypes for aggressive behaviour based on 2-5 SNPs were identified. The frequency of aggressive dogs varied significantly between the haplotypes within loci and the odds ratios of aggression in dogs with risk haplotypes compared with protective haplotypes varied from 4.4 (HTR2C) to 9.0 (SLC6A1). A risk haplotype across the neurotransmitter receptor gene HTR1D harboured a non-synonymous SNP with a potential effect on protein function. We identified no haplotypes in complete association with the recorded phenotypes, supporting a complex inheritance of aggression.
引用
收藏
页码：372 / 378
页数：7
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