Outstanding Questions in Mitophagy: What We Do and Do Not Know

被引：155

作者：

Montava-Garriga, Lambert ^{[1
]}

Ganley, Ian G. ^{[1
]}

机构：

[1] Univ Dundee, MRC Prot Phosphorylat & Ubiquitylat Unit, Sch Life Sci, Dundee DD1 5EH, Scotland

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2020年 / 432卷 / 01期

基金：

英国医学研究理事会;

关键词：

mitophagy; mitochondria; Parkinson's disease; autophagy; metabolism; PATERNAL MITOCHONDRIAL-DNA; LIFE-SPAN EXTENSION; SNARE SYNTAXIN 17; REACTIVE OXYGEN; ULK1; COMPLEX; RAB GTPASES; PINK1-DEPENDENT PHOSPHORYLATION; PINK1/PARKIN-MEDIATED MITOPHAGY; MAMMALIAN MITOPHAGY; OXIDATIVE STRESS;

D O I：

10.1016/j.jmb.2019.06.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The elimination of mitochondria via autophagy, termed mitophagy, is an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. Mitophagy, therefore, has an important contribution to cell function and integrity, which extends to the whole organism for development and survival. Research in mitophagy has boomed in recent years, and it is becoming clear that mitophagy is a complex and multi-factorial cellular response that depends on tissue, energetic, stress and signaling contexts. However, we know very little of its physiological regulation and the direct contribution of mitophagy to pathologies like neurodegenerative diseases. In this review, we aim to discuss the outstanding questions (and questions outstanding) in the field and reflect on our current understanding of mitophagy, the current challenges and the future directions to take. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：206 / 230

页数：25

共 228 条

[1] Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission [J].

Al Rawi, Sara ;

Louvet-Vallee, Sophie ;

Djeddi, Abderazak ;

Sachse, Martin ;

Culetto, Emmanuel ;

Hajjar, Connie ;

Boyd, Lynn ;

Legouis, Renaud ;

Galy, Vincent .

SCIENCE, 2011, 334 (6059) :1144-1147

[2] Loss of iron triggers PINK1/Parkin-independent mitophagy [J].

Allen, George F. G. ;

Toth, Rachel ;

James, John ;

Ganley, Ian G. .

EMBO REPORTS, 2013, 14 (12) :1127-1135

[3] Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance [J].

Altshuler-Keylin, Svetlana ;

Shinoda, Kosaku ;

Hasegawa, Yutaka ;

Ikeda, Kenji ;

Hong, Haemin ;

Kang, Qianqian ;

Yang, Yangyu ;

Perera, Rushika M. ;

Debnath, Jayanta ;

Kajimura, Shingo .

CELL METABOLISM, 2016, 24 (03) :402-419

[4] The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans [J].

Andreux, Penelope A. ;

Blanco-Bose, William ;

Ryu, Dongryeol ;

Burdet, Frederic ;

Ibberson, Mark ;

Aebischer, Patrick ;

Auwerx, Johan ;

Singh, Anurag ;

Rinsch, Chris .

NATURE METABOLISM, 2019, 1 (06) :595-603

[5]

[Anonymous], J BIOPHYS BIOCH CYTO

[6]

[Anonymous], NORMAL DISORDERED RE

[7]

[Anonymous], FRONT CELL DEV BIOL

[8]

[Anonymous], BIOCH BIOPHYS ACTA M

[9]

[Anonymous], DEV CELL

[10] Phosphorylation of Serine 114 on Atg32 mediates mitophagy [J].

Aoki, Yoshimasa ;

Kanki, Tomotake ;

Hirota, Yuko ;

Kurihara, Yusuke ;

Saigusa, Tetsu ;

Uchiumi, Takeshi ;

Kang, Dongchon .

MOLECULAR BIOLOGY OF THE CELL, 2011, 22 (17) :3206-3217

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