A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans

被引：32
作者：
Kohn, MH
Pelz, HJ
机构：
[1] Univ Calif Los Angeles, Dept Organism Biol Ecol & Evolut, Los Angeles, CA 90095 USA
[2] Fed Biol Res Ctr Agr & Forestry, Inst Nematol & Vertebrate Res, Munster, Germany
来源：
BLOOD | 2000年 / 96卷 / 05期
关键词：
D O I：
10.1182/blood.V96.5.1996.h8001996_1996_1998
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The locus underlying hereditary resistance to the anticoagulant warfarin (symbol in the rat, Rw) was placed in relation to 8 positionally mapped gene-anchored microsatellite loci whose positions were known in the genome maps of the rat, mouse, and human. Rw segregated with the markers Myl2 (zero recombinants) and Itgam, II4r, and Fgf2r (one recombinant each) during linkage analysis in a congenic warfarin- and bromadiolone-resistant laboratory strain of rats. Comparative ortholog mapping between rat, mouse, and human placed Rw onto mouse chromosome 7 at about 60 to 63 cM and onto one of the human chromosomes 10q25.3-26, 12q23-q24.3, and 16p13.1-p11. (C) 2000 by The American Society of Hematology.
引用
收藏
页码：1996 / 1998
页数：3
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