Strecker Reaction of Ethyl Cyanoformate with Aldimines Catalyzed by N-Heterocyclic Carbene

被引：8
|
作者：
Zhang, Jie [1 ]
Du, Guangfen [1 ]
Gu, Chengzhi [1 ]
Dai, Bin [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 04期
基金：
中国国家自然科学基金;
关键词：
N-heterocyclic carbenes; Strecker reaction; imines; ethyl cyanoformate; ASYMMETRIC HYDROCYANATION; BENZOIN REACTION; SULFONYLIMINES; CYANATION; ACID; ALDEHYDES; IMINES;
D O I：
10.6023/cjoc201610029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Strecker reaction of ethyl cyanoformate with aldimines was carried out with N-heterocyclic carbene (NHC) as the catalyst. The reaction conditions were optimized with different catalysts, catalyst loading and various solvents. 14 alpha-aminonitriles were synthesized via the optimal reaction conditions. It was found that both aromatic and aliphatic aldimines were suitable electrophiles and the highest yield was 93%. The reaction has the virtue of simple operation, mild reaction condition, high yield and environment friendliness.
引用
收藏
页码：914 / 919
页数：6
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