Evolving Strategies in the Treatment of Tuberous Sclerosis Complex-associated Angiomyolipomas (TSC-AML)

被引：22
作者：
Kapoor, Anil
Girard, Louis
Lattouf, Jean-Baptiste
Pei, York
Rendon, Ricardo
Card, Paul
So, Alan
机构：
[1] McMaster Univ, Div Urol, Hamilton, ON, Canada
[2] Univ Calgary, Dept Med, Calgary, AB T2N 1N4, Canada
[3] Univ Montreal, Dept Surg, Montreal, PQ, Canada
[4] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada
[5] Dalhousie Univ, Dept Urol, QEII Hlth Sci Ctr, Halifax, NS, Canada
[6] Kaleidoscope Strateg, Toronto, ON, Canada
[7] Univ British Columbia, BCCA, Prostate Ctr, Vancouver Gen Hosp, Vancouver, BC V6H 3Z6, Canada
来源：
UROLOGY | 2016年 / 89卷
关键词：
RENAL-CELL CARCINOMA; CONSENSUS CONFERENCE; MTOR INHIBITORS; PHASE-3; TRIAL; MANAGEMENT; EVEROLIMUS; DIAGNOSIS; DISEASE; LYMPHANGIOLEIOMYOMATOSIS; RECOMMENDATIONS;
D O I：
10.1016/j.urology.2015.12.009
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder characterized by the development of numerous benign tumors that occur in multiple organ systems throughout the lifetime of the affected individuals. Renal angiomyolipomas occur in up to 80% of TSC patients, and chronic kidney disease from increasing tumor burden is the primary cause of TSC-related mortality. Our review evaluates evidence for localized and systemic therapy in the management of TSC-angiomyolipomas. Urologists or nephrologists experienced in TSC disease should coordinate the care of TSC patients with renal involvement to improve care and reduce costs. (C) 2016 Elsevier Inc.
引用
收藏
页码：19 / 26
页数：8
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  • [1] Imaging features of tuberous sclerosis complex with autosomal-dominant polycystic kidney disease: a contiguous gene syndrome
    Back, Susan J.
    Andronikou, Savvas
    Kilborn, Tracy
    Kaplan, Bernard S.
    Darge, Kassa
    [J]. PEDIATRIC RADIOLOGY, 2015, 45 (03) : 386 - 395
  • [2] Renal angiomyolipomata
    Bissler, JJ
    Kingswood, JC
    [J]. KIDNEY INTERNATIONAL, 2004, 66 (03) : 924 - 934
  • [3] Reduction of postembolization syndrome after ablation of renal angiomyolipoma
    Bissler, JJ
    Racadio, J
    Donnelly, LF
    Johnson, ND
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (05) : 966 - 971
  • [4] Bissler JJ, 2014, European Urology Supplements, V13, pe1139
  • [5] Bissler JJ., 2015, EUR UROL SUPPL, V14, DOI [10.1016/S1569-9056(15)60004-5, DOI 10.1016/S1569-9056(15)60004-5]
  • [6] Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    Bissler, John J.
    McCormack, Francis X.
    Young, Lisa R.
    Elwing, Jean M.
    Chuck, Gail
    Leonard, Jennifer M.
    Schmithorst, Vincent J.
    Laor, Tal
    Brody, Alan S.
    Bean, Judy
    Salisbury, Shelia
    Franz, David N.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (02) : 140 - 151
  • [7] Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
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    Kingswood, J. Christopher
    Radzikowska, Elzbieta
    Zonnenberg, Bernard A.
    Frost, Michael
    Belousova, Elena
    Sauter, Matthias
    Nonomura, Norio
    Brakemeier, Susanne
    de Vries, Petrus J.
    Whittemore, Vicky H.
    Chen, David
    Sahmoud, Tarek
    Shah, Gaurav
    Lincy, Jeremie
    Lebwohl, David
    Budde, Klemens
    [J]. LANCET, 2013, 381 (9869) : 817 - 824
  • [8] Laparoscopic cryoablation of renal angiomyolipoma
    Byrd, Gregory F.
    Lawatsch, Eric J.
    Mesrobian, Hrair-George
    Begun, Frank
    Langenstroer, Peter
    [J]. JOURNAL OF UROLOGY, 2006, 176 (04) : 1512 - 1516
  • [9] Assessing the effectiveness of rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial
    Cabrera-Lopez, Cristina
    Marti, Teresa
    Catala, Violeta
    Torres, Ferran
    Mateu, Silvia
    Ballarin, Jose
    Torra, Roser
    [J]. ORPHANET JOURNAL OF RARE DISEASES, 2012, 7
  • [10] Multidisciplinary Care Program for Advanced Chronic Kidney Disease: Reduces Renal Replacement and Medical Costs
    Chen, Ping Min
    Lai, Tai Shuan
    Chen, Ping Yu
    Lai, Chun Fu
    Yang, Shao Yu
    Wu, VinCent
    Chiang, Chih Kang
    Kao, Tze Wah
    Huang, Jenq Wen
    Chiang, Wen Chih
    Lin, Shuei Liong
    Hung, Kuan Yu
    Chen, Yung Ming
    Chu, Tzong Shinn
    Wu, Ming Shiou
    Wu, Kwan Dun
    Tsai, Tun Jun
    [J]. AMERICAN JOURNAL OF MEDICINE, 2015, 128 (01) : 68 - 76
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