Immune and Inflammatory Networks in Myocardial Infarction: Current Research and Its Potential Implications for the Clinic

被引:34
作者
Anzai, Atsushi [1 ]
Ko, Seien [1 ]
Fukuda, Keiichi [1 ]
机构
[1] Keio Univ, Sch Med, Dept Cardiol, Tokyo 1608582, Japan
关键词
myocardial infarction; heart failure; innate immunity; adaptive immunity; immune cells; inflammation; cytokines; chemokines; growth factors; hematopoiesis; clonal hematopoiesis; immunotherapy; clinical trial; PATTERN-RECOGNITION RECEPTORS; HEART-FAILURE EVENTS; CLONAL HEMATOPOIESIS; CARDIAC-FUNCTION; T-CELLS; MONOCYTE SUBSETS; DENDRITIC CELLS; INNATE IMMUNITY; MACROPHAGES; ATHEROSCLEROSIS;
D O I
10.3390/ijms23095214
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Despite recent scientific and technological advances, myocardial infarction (MI) still represents a major global health problem, leading to high morbidity and mortality worldwide. During the post-MI wound healing process, dysregulated immune inflammatory pathways and failure to resolve inflammation are associated with maladaptive left ventricular remodeling, progressive heart failure, and eventually poor outcomes. Given the roles of immune cells in the host response against tissue injury, understanding the involved cellular subsets, sources, and functions is essential for discovering novel therapeutic strategies that preserve the protective immune system and promote optimal healing. This review discusses the cellular effectors and molecular signals across multi-organ systems, which regulate the inflammatory and reparative responses after MI. Additionally, we summarize the recent clinical and preclinical data that propel conceptual revolutions in cardiovascular immunotherapy.
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页数:20
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