Quantification of Ocular Biomechanics In Ocular Manifestations of Systemic Autoimmune Diseases

被引：13

作者：

Mahendradas, Padmamalini ^{[1
,2
]}

Francis, Mathew ^{[3
]}

Vala, Ruchi ^{[4
,5
]}

Gowda, Poornachandra B. ^{[1
,2
]}

Kawali, Ankush ^{[1
,2
]}

Shetty, Rohit ^{[1
,2
]}

Roy, Abhijit Sinha ^{[3
]}

机构：

[1] Narayana Nethralaya, Uveitis Serv, Bangalore, Karnataka, India

[2] Narayana Nethralaya, Ocular Immunol Serv, Bangalore, Karnataka, India

[3] Narayana Nethralaya Fdn, Imaging Biomech & Math Modeling Solut, Bangalore, Karnataka, India

[4] Narayana Nethralaya, Cornea Serv, Bangalore, Karnataka, India

[5] Narayana Nethralaya, Refract Serv, Bangalore, Karnataka, India

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2019年 / 27卷 / 07期

关键词：

Ankylosing spondylitis; corneal stiffness; corvis-ST; extracorneal stiffness; granulomatosis with polyangitis; ocular biomechanics; rheumatoid arthritis; sarcoidosis; systemic autoimmune diseases; systemic lupus erythematosus; INTRAOCULAR-PRESSURE; RHEUMATOID-ARTHRITIS; DRY EYE; CORNEAL; KERATOCONUS; STIFFNESS; PATIENT; LASIK;

D O I：

10.1080/09273948.2018.1501491

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To quantify biomechanical change associated with autoimmune diseases using Corvis ST deformation data. Methods: Cross-sectional, observational, case control study of 76 patients with systemic autoimmune disease and 21 control subjects. All patients underwent detailed ophthalmic examination with Corvis-ST (Oculus Optikgerate Gmbh, Germany) measurements for biomechanical properties of the eye. Corneal deformation and also deformation caused by the extracorneal tissue were recorded. Using a mathematical formula, the three parameters, namely, corneal stiffness (kc), extracorneal tissue stiffness (kg), and extracorneal tissue viscosity (?g), were defined. Results: The biomechanical analysis showed that kc and ?g were significantly lower in patients with systemic autoimmune disease with eye manifestations than control group. However statistically, it was significant in rheumatoid arthritis (RA) patients only. Conclusion: The new parameters, namely, kc, kg, and ?g, can provide a sensitive marker of the ocular activity of the collagen vascular diseases.

引用

页码：1127 / 1137

页数：11

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