In Vitro Evaluation of the Individual and Combined Cytotoxic and Estrogenic Effects of Zearalenone, Its Reduced Metabolites, Alternariol, and Genistein

被引：25

作者：

Balazs, Adrienn ^{[1
]}

Faisal, Zelma ^{[2
,3
]}

Csepregi, Rita ^{[4
,5
]}

Koszegi, Tamas ^{[3
,4
,5
]}

Kriszt, Balazs ^{[6
]}

Szabo, Istvan ^{[1
]}

Poor, Miklos ^{[2
,3
]}

机构：

[1] Hungarian Univ Agr & Life Sci, Inst Aquaculture & Environm Safety, Dept Environm Toxicol, Pater Karoly U 1, H-2100 Godollo, Hungary

[2] Univ Pecs, Fac Pharm, Dept Pharmacol, Rokus U 2, H-7624 Pecs, Hungary

[3] Univ Pecs, Janos Szentagothai Res Ctr, Food Biotechnol Res Grp, Ifjusag Utja 20, H-7624 Pecs, Hungary

[4] Univ Pecs, Janos Szentagothai Res Ctr, Lab Chip Res Grp, Ifjusag Utja 20, H-7624 Pecs, Hungary

[5] Univ Pecs, Med Sch, Dept Lab Med, Ifjusag Utja 3, H-7624 Pecs, Hungary

[6] Hungarian Univ Agr & Life Sci, Inst Aquaculture & Environm Safety, Dept Environm Safety, Pater Karoly U 1, H-2100 Godollo, Hungary

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 12期

关键词：

zearalenone; reduced zearalenone metabolites; alternariol; genistein; cytotoxicity; estrogenicity; combined effects; co-exposure; 16 FUSARIUM TOXINS; ALPHA-ZEARALENOL; BETA-ZEARALENOL; MYCOTOXIN ALTERNARIOL; NATURAL OCCURRENCE; DEGRADATION-PRODUCTS; OCHRATOXIN; MECHANISMS; CHEMICALS; MOLDS;

D O I：

10.3390/ijms22126281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycotoxins are toxic metabolites of filamentous fungi. Previous studies demonstrated the co-occurrence of Fusarium and Alternaria toxins, including zearalenone (ZEN), ZEN metabolites, and alternariol (AOH). These xenoestrogenic mycotoxins appear in soy-based meals and dietary supplements, resulting in the co-exposure to ZEN and AOH with the phytoestrogen genistein (GEN). In this study, the cytotoxic and estrogenic effects of ZEN, reduced ZEN metabolites, AOH, and GEN are examined to evaluate their individual and combined impacts. Our results demonstrate that reduced ZEN metabolites, AOH, and GEN can aggravate ZEN-induced toxicity; in addition, the compounds tested exerted mostly synergism or additive combined effects regarding cytotoxicity and/or estrogenicity. Therefore, these observations underline the importance and the considerable risk of mycotoxin co-exposure and the combined effects of mycoestrogens with phytoestrogens.

引用

页数：15

共 69 条

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