Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes

被引：17

作者：

Zhang, Hong ^{[1
]}

Wu, Xinxin ^{[1
]}

Wei, Yunlong ^{[1
]}

Zhu, Chen ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synth Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 18期

基金：

中国国家自然科学基金;

关键词：

DIELS-ALDER REACTIONS; NATURAL-PRODUCTS; EFFICIENT; CATALYST; POLYMERIZATION; ALKENYLATION; OLEFINATION; GENERATION; STRATEGIES; MARINE;

D O I：

10.1021/acs.orglett.9b02838

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed alkenes are harnessed as starting material, leading to a unique stereoisomer of polyenes. In addition, the transformation features mild reaction conditions and broad functional group compatibility. A variety of valuable 1,3-dienes and 1,3,5-trienes are afforded in useful yields.

引用

页码：7568 / 7572

页数：5

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