Longitudinal Effects of Physical Activity Change on Hippocampal Volumes over up to 12 Years in Middle and Older Age Community-Dwelling Individuals

被引:4
|
作者
Fraser, Mark A. [1 ]
Walsh, Erin, I [1 ,2 ]
Shaw, Marnie E. [3 ]
Anstey, Kaarin J. [1 ,4 ,5 ]
Cherbuin, Nicolas [1 ]
机构
[1] Australian Natl Univ, Res Sch Populat Hlth, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT 2601, Australia
[2] Australian Natl Univ, Res Sch Populat Hlth, Populat Hlth Exchange, Canberra, ACT 2601, Australia
[3] Australian Natl Univ, ANU Coll Engn & Comp Sci, Canberra, ACT 2600, Australia
[4] Univ New South Wales, Ageing Futures Inst, Sydney, NSW 2052, Australia
[5] Neurosci Res Australia, Sydney, NSW 2031, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
aging; APOE; healthy individuals; magnetic resonance imaging; physical activity; AEROBIC EXERCISE; BRAIN; PATH; ASYMMETRY; AMYGDALA; MEMORY; ADULTS; HEALTH; IMPACT; SEX;
D O I
10.1093/cercor/bhab375
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The objectives of this study were to investigate the long-term associations between changes in physical activity levels and hippocampal volumes over time, while considering the influence of age, sex, and APOE-epsilon 4 genotype. We investigated the effects of change in physical activity on hippocampal volumes in 411 middle age (mean age = 47.2 years) and 375 older age (mean age = 63.1 years) adults followed up to 12 years. An annual volume decrease was observed in the left (middle age: 0.46%; older age: 0.51%) but not in the right hippocampus. Each additional 10 metabolic equivalents (METs, similar to 2 h of moderate exercise) increase in weekly physical activity was associated with 0.33% larger hippocampal volume in middle age (equivalent to similar to 1 year of typical aging). In older age, each additional MET was associated with 0.05% larger hippocampal volume; however, the effects declined with time by 0.005% per year. For older age APOE-epsilon 4 carriers, each additional MET was associated with a 0.10% increase in hippocampal volume. No sex effects of physical activity change were found. Increasing physical activity has long-term positive effects on hippocampal volumes and appears especially beneficial for older APOE-epsilon 4 carriers. To optimize healthy brain aging, physical activity programs should focus on creating long-term exercise habits.
引用
收藏
页码:2705 / 2716
页数:12
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