Prognostic significance of erythropoietin expression in human renal cell carcinoma

被引:15
作者
Michael, Agniezka
Politi, Ekaterini
Havranek, Erik
Corbishley, Catherine
Karapanagiotou, Lena
Anderson, Chris
Relph, Kate
Syrigos, Konstantinos N.
Pandha, Hardev
机构
[1] St George Hosp, Med Sch, Dept Oncol, London SW17 0RE, England
[2] St George Hosp, Med Sch, Dept Urol, London SW17 0RE, England
[3] Sotiria Gen Hosp, Athens Sch Med, Dept Med 3, Oncol Unit, Athens, Greece
关键词
RCC; erythropoietin; survival; marker; prognosis;
D O I
10.1111/j.1464-410X.2007.06978.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objectives To investigate, in a retrospective study, the expression of erythropoietin (Epo) in human renal cell carcinoma (RCC) and its correlation with overall survival, as Epo (an haematopoietic cytokine that regulates the production of red blood cells), with its receptor, was recently localized in non-haematopoietic tissues, e.g. liver, uterus, central nervous system, vascular endothelial cells and solid tumours. Patients and methods We used data from 113 patients who had radical nephrectomy for RCC between 1990 and 2000, taking sections from formalin-fixed and paraffin wax-embedded tissue blocks. The association between Epo staining and the patients' characteristics was assessed by either chi-squared tests (for categorical variables) or two-sample independent t-tests (for continuous variables). Results Tissue from 37 patients (33%) was positive for cytoplasmic Epo expression; 76 (67%) samples were negative. Univariate hazard ratio analysis confirmed that those with positive Epo staining were more than twice as likely to die as those with negative staining (hazard ratio 2.34, 95% confidence interval 1.27-4.3). Conclusion This study shows that the expression of Epo in RCC is adversely associated with overall survival. This is the first report of such an association, and might be explained by the loss of Von Hippel-Lindau protein function in clear cell RCC. The expression of Epo might have potential use in clinical trials when stratifying high-risk patients for adjuvant therapy after nephrectomy.
引用
收藏
页码:291 / 294
页数:4
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