Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

被引：101

作者：

Malishev, Ravit ^{[1
]}

Arad, Elad ^{[1
]}

Bhunia, Susanta Kumar ^{[1
]}

Shaham-Niv, Shira ^{[2
]}

Kolusheva, Sofiya ^{[3
]}

Gazit, Ehud ^{[2
,4
]}

Jelinek, Raz ^{[1
,3
]}

机构：

[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

[2] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-69978 Tel Aviv, Israel

[3] Ben Gurion Univ Negev, Ilse Katz Inst Nanotechnol, IL-84105 Beer Sheva, Israel

[4] Tel Aviv Univ, Iby & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, IL-69978 Tel Aviv, Israel

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 56期

关键词：

ATOMIC-RESOLUTION STRUCTURE; SMALL-MOLECULE INHIBITORS; GRAPHENE QUANTUM DOTS; ALZHEIMERS-DISEASE; IN-VITRO; AGGREGATION; PEPTIDE; TOXICITY; NANOPARTICLES; OLIGOMERS;

D O I：

10.1039/c8cc03235a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (A42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l-Lys-C-dots dramatically remodeled A42 secondary structure and fibril morphologies, as well as inhibited A42 cytotoxicity and membrane interactions.

引用

页码：7762 / 7765

页数：4

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