Enrichment and separation of chlorogenic acid from the extract of Eupatorium adenophorum Spreng by macroporous resin

被引：46
作者：
Liu, Boyan [1 ,2 ]
Dong, Beitao [1 ,2 ]
Yuan, Xiaofan [1 ]
Kuang, Qirong [1 ]
Zhao, Qingsheng [1 ]
Yang, Mei [3 ]
Liu, Jie [3 ]
Zhao, Bing [1 ]
机构：
[1] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
[3] Panzhihua Xiyu Biotech Co Ltd, Panzhihua 617400, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2016年 / 1008卷
关键词：
NKA-II macroporous resin; Chlorogenic acid; Eupatorium adenophorum Spreng; Separation; ADSORPTION; RESOURCE; CHINA; PLANT;
D O I：
10.1016/j.jchromb.2015.10.026
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and efficient chromatographic method for separation of chlorogenic acid from Eupatorium adenophorum Spreng extract was developed. The adsorption properties of nine macroporous resins were evaluated. NKA-II resin showed much better adsorption/desorption properties. The adsorption of chlorogenic acid on NKA-II resin at 25 degrees C was well fitted to Langmuir isotherm model and pseudo-second-order kinetic model. The dynamic adsorption and desorption experiments were carried out on columns packed with NKA-II resin to optimize the separation process. The content of chlorogenic acid in the product increased to 22.17%, with a recovery yield of 82.41%. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：58 / 64
页数：7
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