I2/FeCl3 Promoted Cascade Reaction of 4-Quinazolinone, Pyridine, and Chalcone for the Synthesis of Indolizines

被引：1

作者：

Meena, Mahesh ^{[1
]}

Malviya, Bhanwar K. ^{[1
]}

Singh, Karandeep ^{[1
]}

Yadav, Priyanka ^{[2
]}

Naharwal, Pankaj ^{[1
]}

Kumari, Neetu ^{[1
]}

Verma, Ved Prakash ^{[2
]}

Yadav, Dinesh K. ^{[1
]}

Sharma, Siddharth ^{[1
]}

机构：

[1] Mohanlal Sukhadia Univ, Dept Chem, Udaipur 313001, Rajasthan, India

[2] Banasthali Univ, Dept Chem, Newai Jodhpuriya Rd, Vanasthali, India

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 21期

关键词：

Chalcone; Cycloaddition; Indolizines; Quinazolinone; Zwitterions; DERIVATIVES; INHIBITORS; POTENT; FLUORESCENCE;

D O I：

10.1002/slct.202201378

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The indolizines nucleus is an important element of many synthetic molecules with significant biological activity. An efficient methodology for the synthesis of a variety of indolizines from quinazolinone, pyridine, and chalcone via I-2/FeCl3 has been described. The reaction was promoted through Zwitterion formation/cyclization/aromatization sequence, affording the desired products in moderate to very good yields. This approach is a highly efficient and convenient way to get derivatives of indolizines from readily accessible substrate under relatively mild reaction conditions.

引用

页数：6

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