Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

被引:14
作者
Yu, Haiyang [1 ]
Cleveland, Don W. [1 ,2 ]
机构
[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
关键词
ALS; GENES;
D O I
10.1016/j.cell.2018.08.035
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
引用
收藏
页码:1339 / 1341
页数:3
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