Class switch recombination: A friend and a foe

被引：11

作者：

Edry, Efrat

Melamed, Doron ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Fac Med, Bruce Rappaport Fac Med, Dept Immunol, Haifa, Israel

[2] Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, Haifa, Israel

来源：

CLINICAL IMMUNOLOGY | 2007年 / 123卷 / 03期

关键词：

class switch recombination; switch regions; somatic hypermutation; genetic instability; translocation; activation-induced deaminase; germline transcription; DNA repair;

D O I：

10.1016/j.clim.2007.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effector functions of the antibody are determined by the heavy chain constant region (CH). During CSR the primarily expressed p constant region (C mu) of the heavy chain is replaced with a downstream isotype C gamma, C alpha or C epsilon. The murine immunoglobulin heavy chain (IgH) locus contains eight different CH genes. Class switch recombination (CSR) involves a recombination between two different repetitive switch (S) region sequences, located upstream of each CH gene and the deletion of the intervening DNA. However, this protecting mechanism is also involved in aberrant chromosomal translocations and generation of B cell malignancies. It is also involved in susceptibility to autoimmunity. The current review focuses on the basic mechanism of CSR and the adverse outcomes that it may cause. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：244 / 251

页数：8

共 101 条

[1] Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].