A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography

被引：3
|
作者：
Vitkova, Katerina [1 ]
Pechova, Marketa [2 ]
Petr, Jan [3 ]
Znaleziona, Joanna [1 ]
Ranc, Vaclav [1 ]
Maier, Vitezslav [1 ]
Sevcik, Juraj [1 ]
机构：
[1] Palacky Univ, Fac Sci, Dept Analyt Chem, CZ-77146 Olomouc, Czech Republic
[2] Univ Hosp, Dept Clin Biochem, CZ-77520 Olomouc, Czech Republic
[3] Chim ParisTech, Ecole Natl Super Chim, CNRS,UMR 7195, Lab Physicochem Electrolytes Colloids & Analyt Sc, F-75231 Paris 05, France
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2010年 / 8卷 / 02期
关键词：
Micellar electrokinetic chromatography; Yohimbine; Pharmaceuticals; PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY-ELECTROPHORESIS; METABOLISM; SEPARATION; STACKING; HUMANS;
D O I：
10.2478/s11532-009-0149-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the fast determination of yohimbine, a potent adrenoreceptor antagonist used for the treatment of sexual dysfunctions, is proposed in this article. MEKC under basic and acidic conditions (sodium borate, pH 9.5 and sodium phosphate, pH 2.5) with SDS was developed. The effect of the experimental parameters, e. g. pH, SDS concentration and injection time, on yohimbine migration was also studied. Both methods were validated in terms of linearity, limits of detection and quantification, accuracy, and precision using caffeine as an internal standard. The application for the determination of yohimbine in hand-made medicaments is also investigated in this study.
引用
收藏
页码：273 / 277
页数：5
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