Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii

被引：23

作者：

Yang, Da-Song ^{[1
,2
,3
]}

Wei, Jian-Guo ^{[1
,2
,3
]}

Peng, Wei-Bing ^{[4
]}

Wang, Shuang-Mei ^{[1
,2
,3
]}

Sun, Chen ^{[4
]}

Yang, Yong-Ping ^{[1
,2
,3
]}

Liu, Ke-Chun ^{[4
]}

Li, Xiao-Li ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China

[2] Chinese Acad Sci, Germplasm Bank Wild Species Southwest China, Kunming 650201, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650201, Peoples R China

[4] Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China

来源：

FITOTERAPIA | 2014年 / 99卷

基金：

中国国家自然科学基金;

关键词：

Macaranga kurzii; Euphorbiaceae; Prenylated flavonoids; Prenylated bibenzyls; Cytotoxicity; SESQUITERPENYL SIDE-CHAIN; PHENOLIC DERIVATIVES; CONSTITUENTS; LEAVES; CHEMOSYSTEMATICS; COMPONENTS; BRYOPHYTES; STILBENES; PLANTS;

D O I：

10.1016/j.fitote.2014.10.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：261 / 266

页数：6

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