Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii

被引：23
|
作者：
Yang, Da-Song [1 ,2 ,3 ]
Wei, Jian-Guo [1 ,2 ,3 ]
Peng, Wei-Bing [4 ]
Wang, Shuang-Mei [1 ,2 ,3 ]
Sun, Chen [4 ]
Yang, Yong-Ping [1 ,2 ,3 ]
Liu, Ke-Chun [4 ]
Li, Xiao-Li [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
[2] Chinese Acad Sci, Germplasm Bank Wild Species Southwest China, Kunming 650201, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650201, Peoples R China
[4] Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China
来源：
FITOTERAPIA | 2014年 / 99卷
基金：
中国国家自然科学基金;
关键词：
Macaranga kurzii; Euphorbiaceae; Prenylated flavonoids; Prenylated bibenzyls; Cytotoxicity; SESQUITERPENYL SIDE-CHAIN; PHENOLIC DERIVATIVES; CONSTITUENTS; LEAVES; CHEMOSYSTEMATICS; COMPONENTS; BRYOPHYTES; STILBENES; PLANTS;
D O I：
10.1016/j.fitote.2014.10.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：261 / 266
页数：6
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