Functionalized carbon nanotubes for plasmid DNA gene delivery

被引：735
作者：
Pantarotto, D
Singh, R
McCarthy, D
Erhardt, M
Briand, JP
Prato, M [1 ]
Kostarelos, K
Bianco, A
机构：
[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy
[2] Univ London, Sch Pharm, Electron Microscopy Unit, London WC1N 1AX, England
[3] Univ London, Sch Pharm, Ctr Drug Delivery Res, London WC1N 1AX, England
[4] CNRS, UPR9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France
[5] Inst Biol Mol Plantes, F-67084 Strasbourg, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 39期
关键词：
carbon nanotubes; gene delivery; plasmid DNA; supramolecular chemistry;
D O I：
10.1002/anie.200460437
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.
引用
收藏
页码：5242 / 5246
页数：5
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