A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut

被引：32

作者：

Park, Jeong-Ho ^{[1
]}

Chen, Ji ^{[1
]}

Jang, Sooin ^{[1
]}

Ahn, Tae Jung ^{[2
]}

Kang, KyeongJin ^{[2
]}

Choi, Min Sung ^{[1
]}

Kwon, Jae Young ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Biol Sci, 2066 Seobu Ro, Suwon 16419, South Korea

[2] Sungkyunkwan Univ, Samsung Biomed Res Inst, Sch Med, Dept Anat & Cell Biol, Suwon, South Korea

来源：

FEBS LETTERS | 2016年 / 590卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

amino acids; CaLexA system; chemosensing; Drosophila melanogaster; enteroendocrine cells; GLUCAGON-LIKE PEPTIDE-1; STEM-CELLS; POSTERIOR MIDGUT; TASTE RECEPTORS; SECRETION; HOMEOSTASIS; EXPRESSION; GUSTDUCIN; STORAGE; FAMILY;

D O I：

10.1002/1873-3468.12073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intestine is involved in digestion and absorption, as well as the regulation of metabolism upon sensation of the internal intestinal environment. Enteroendocrine cells are thought to mediate these internal intestinal chemosensory functions. Using the CaLexA (calcium-dependent nuclear import of LexA) method, we examined the enteroendocrine cell populations that are activated when flies are subjected to various dietary conditions such as starvation, sugar, high fat, protein, or pathogen exposure. We find that a specific subpopulation of enteroendocrine cells in the posterior midgut which express Dh31 and tachykinin are activated by the presence of proteins and amino acids.

引用

页码：493 / 500

页数：8

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