Review of Progress in Predicting Protein Methylation Sites

被引：10

作者：

Ao, Chunyan ^{[1
]}

Jin, Shunshan ^{[2
]}

Lin, Yuan ^{[3
]}

Zou, Quan ^{[1
,4
]}

机构：

[1] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Chengdu, Sichuan, Peoples R China

[2] Heilongjiang Prov Land Reclamat Headquarters Gen, Dept Neurol, Harbin, Heilongjiang, Peoples R China

[3] Sparebanken Vest, Dept Syst Integrat, Bergen, Norway

[4] Univ Elect Sci & Technol China, Cente Informat Biol, Chengdu, Sichuan, Peoples R China

来源：

CURRENT ORGANIC CHEMISTRY | 2019年 / 23卷 / 15期

关键词：

Protein methylation; Support Vector Machine (SVM); methyllysine; methylarginine; arginine residue; lysine residue; cysteine residues; LYSINE SUCCINYLATION SITES; ARGININE METHYLATION; POSTTRANSLATIONAL MODIFICATIONS; HISTONE H3; IDENTIFICATION; CITRULLINATION; ACETYLATION; EXPRESSION; DATABASE; ENZYMES;

D O I：

10.2174/1385272823666190723141347

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protein methylation is an important and reversible post-translational modification that regulates many biological processes in cells. It occurs mainly on lysine and arginine residues and involves many important biological processes, including transcriptional activity, signal transduction, and the regulation of gene expression. Protein methylation and its regulatory enzymes are related to a variety of human diseases, so improved identification of methylation sites is useful for designing drugs for a variety of related diseases. In this review, we systematically summarize and analyze the tools used for the prediction of protein methylation sites on arginine and lysine residues over the last decade.

引用

页码：1663 / 1670

页数：8

共 111 条

[1] Protein methylation: a signal event in post-translational modification [J].

Aleta, JM ;

Cimato, TR ;

Ettinger, MJ .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (03) :89-91

[2] EPSILON-N-METHYL-LYSINE IN BACTERIAL FLAGELLAR PROTEIN [J].

AMBLER, RP ;

REES, MW .

NATURE, 1959, 184 (4679) :56-57

[3] Reversing histone methylation [J].

Bannister, AJ ;

Kouzarides, T .

NATURE, 2005, 436 (7054) :1103-1106

[4] UniProt: a hub for protein information [J].

Bateman, Alex ;

Martin, Maria Jesus ;

O'Donovan, Claire ;

Magrane, Michele ;

Apweiler, Rolf ;

Alpi, Emanuele ;

Antunes, Ricardo ;

Arganiska, Joanna ;

Bely, Benoit ;

Bingley, Mark ;

Bonilla, Carlos ;

Britto, Ramona ;

Bursteinas, Borisas ;

Chavali, Gayatri ;

Cibrian-Uhalte, Elena ;

Da Silva, Alan ;

De Giorgi, Maurizio ;

Dogan, Tunca ;

Fazzini, Francesco ;

Gane, Paul ;

Cas-tro, Leyla Garcia ;

Garmiri, Penelope ;

Hatton-Ellis, Emma ;

Hieta, Reija ;

Huntley, Rachael ;

Legge, Duncan ;

Liu, Wudong ;

Luo, Jie ;

MacDougall, Alistair ;

Mutowo, Prudence ;

Nightin-gale, Andrew ;

Orchard, Sandra ;

Pichler, Klemens ;

Poggioli, Diego ;

Pundir, Sangya ;

Pureza, Luis ;

Qi, Guoying ;

Rosanoff, Steven ;

Saidi, Rabie ;

Sawford, Tony ;

Shypitsyna, Aleksandra ;

Turner, Edward ;

Volynkin, Vladimir ;

Wardell, Tony ;

Watkins, Xavier ;

Zellner, Hermann ;

Cowley, Andrew ;

Figueira, Luis ;

Li, Weizhong ;

McWilliam, Hamish .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D204-D212

[5] Arginine methylation: An emerging regulator of protein function [J].

Bedford, MT ;

Richard, S .

MOLECULAR CELL, 2005, 18 (03) :263-272

[6] Random forests [J].

Breiman, L .

MACHINE LEARNING, 2001, 45 (01) :5-32

[7]

Brinkmann SJH, 2014, CURR OPIN CLIN NUTR, V17, P90, DOI 10.1097/MCO.0000000000000020

[8] Spiking Neural P Systems With Scheduled Synapses [J].

Cabarle, Francis George C. ;

Adorna, Henry N. ;

Jiang, Min ;

Zeng, Xiangxiang .

IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2017, 16 (08) :792-801

[9] LIBSVM: A Library for Support Vector Machines [J].

Chang, Chih-Chung ;

Lin, Chih-Jen .

ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY, 2011, 2 (03)

[10] MeMo: a web tool for prediction of protein methylation modifications [J].

Chen, Hu ;

Xue, Yu ;

Huang, Ni ;

Yao, Xuebiao ;

Sun, Zhirong .

NUCLEIC ACIDS RESEARCH, 2006, 34 :W249-W253

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