The emerging role of extracellular vesicles as biomarkers for urogenital cancers

被引：253

作者：

Nawaz, Muhammad ^{[1
]}

Camussi, Giovanni ^{[2
]}

Valadi, Hadi ^{[3
]}

Nazarenko, Irina ^{[4
]}

Ekstrom, Karin ^{[3
]}

Wang, Xiaoqin ^{[3
]}

Principe, Simona ^{[5
]}

Shah, Neelam ^{[6
]}

Ashraf, Naeem M. ^{[7
]}

Fatima, Farah ^{[1
]}

Neder, Luciano ^{[1
]}

Kislinger, Thomas ^{[5
]}

机构：

[1] Univ Sao Paulo, BR-05508 Sao Paulo, Brazil

[2] Univ Turin, I-10124 Turin, Italy

[3] Univ Gothenburg, BIOMATCELL VINN Excellence Ctr Biomat & Cell Ther, Gothenburg, Sweden

[4] Univ Med Ctr Freiburg, Freiburg, Germany

[5] Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada

[6] Monash Univ, Clayton, Vic 3800, Australia

[7] Univ Gujrat, Gujrat, Pakistan

来源：

NATURE REVIEWS UROLOGY | 2014年 / 11卷 / 12期

基金：

巴西圣保罗研究基金会; 瑞典研究理事会;

关键词：

RENAL-CELL CARCINOMA; MULTIVESICULAR BODY BIOGENESIS; TUMOR-DERIVED MICROVESICLES; FLOW-CYTOMETRIC ANALYSIS; HUMAN URINARY EXOSOMES; PROSTATE-CANCER; BLADDER-CANCER; PLASMA-MEMBRANE; POTENTIAL BIOMARKERS; CIRCULATING MICRORNA;

D O I：

10.1038/nrurol.2014.301

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.

引用

页码：688 / 701

页数：14

共 168 条

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